Mac and Cheese Chicken Alfredo

Featured in: Hearty Dinners

This casserole features perfectly cooked elbow macaroni with tender chicken breast, enveloped in a velvety blend of mozzarella, cheddar, Parmesan, cream, and milk. Enhanced by a touch of garlic, nutmeg, and a crispy panko-Parmesan topping, it's baked until golden and bubbling. The result is a warmly satisfying main dish that's creamy, savory, and texturally rich, ideal for family gatherings and cozy evenings. Pair with a fresh green salad for balance, and easily adapt with favorite cheeses or add-ins like broccoli or mushrooms for extra flair.

Updated on Mon, 27 Oct 2025 10:21:00 GMT
Creamy Mac and Cheese Chicken Alfredo Bake topped with golden breadcrumbs and parsley.  Save It
Creamy Mac and Cheese Chicken Alfredo Bake topped with golden breadcrumbs and parsley. | sunnyspoonful.com

A rich and comforting baked casserole combining creamy mac and cheese with tender chicken and a luscious Alfredo sauce, finished with a golden breadcrumb topping.

I still remember the first time I made this for my family, right after a chilly autumn soccer game. Everyone dug in enthusiastically, and the bubbling cheese quickly made it a weeknight favorite at our house.

Ingredients

  • Elbow macaroni: 12 oz (340 g)
  • Chicken breast: 2 cups (about 280 g), cooked, diced or shredded
  • Mozzarella cheese: 2 cups (200 g), shredded
  • Sharp cheddar cheese: 1 cup (100 g), shredded
  • Parmesan cheese: 1/2 cup (50 g), grated
  • Heavy cream: 2 cups (480 ml)
  • Whole milk: 1 cup (240 ml)
  • Unsalted butter: 4 tbsp (60 g)
  • Garlic: 4 cloves, minced
  • Salt: 1/2 tsp
  • Freshly ground black pepper: 1/2 tsp
  • Ground nutmeg: 1/4 tsp (optional)
  • Panko breadcrumbs: 1 cup (60 g)
  • Melted butter: 2 tbsp (30 g)
  • Grated Parmesan cheese: 2 tbsp (20 g)
  • Fresh parsley: 2 tbsp, chopped (optional)

Instructions

Preheat oven:
Set oven to 375°F (190°C). Grease a 9x13-inch (23x33 cm) baking dish.
Cook pasta:
Prepare macaroni in a large pot according to package directions until al dente. Drain and set aside.
Make sauce base:
In a large saucepan over medium heat, melt 4 tbsp butter. Add minced garlic and cook for 1<strong>2 minutes until fragrant.
Add liquids and seasonings:
Stir in heavy cream and milk, then salt, pepper, and nutmeg. Bring to a gentle simmer, but do not boil.
Incorporate cheeses:
Lower heat and whisk in mozzarella, cheddar, and Parmesan until melted and smooth.
Add pasta and chicken:
Stir macaroni and chicken into the sauce, coating everything evenly.
Assemble casserole:
Transfer mixture to the baking dish.
Make topping:
Mix panko breadcrumbs, melted butter, and Parmesan in a small bowl. Sprinkle over casserole.
Bake:
Bake uncovered for 20<strong>25 minutes, until top is golden and sauce bubbles.
Garnish and serve:
Remove from oven and let stand 5 minutes. Sprinkle with parsley before serving if desired.
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One evening, everyone sat around the kitchen counter helping to grate cheese and chop parsley. It turned dinner into a fun bonding moment, making every bite taste even better.

Serving Suggestions

This casserole is delicious with a crisp green salad or garlic bread to soak up extra sauce.

Substitutions &amp; Add-Ons

You can substitute rotisserie chicken for convenience, or add steamed broccoli or sautéed mushrooms for extra veggies.

Required Kitchen Tools

Having a large saucepan, pot, mixing bowls, whisk, and a 9x13-inch baking dish ensures smooth prep.

A mouthwatering Mac and Cheese Chicken Alfredo Bake bursting with creamy flavors and tender chicken.  Save It
A mouthwatering Mac and Cheese Chicken Alfredo Bake bursting with creamy flavors and tender chicken. | sunnyspoonful.com

This bake is sure to warm up any gathering and leftovers taste just as good reheated the next day.

Recipe FAQs

What type of pasta works best for this bake?

Elbow macaroni is ideal for holding the sauce, but you may try penne or rotini for similar results.

Can I substitute the chicken?

Yes, rotisserie or leftover chicken is convenient, or swap with turkey or cooked sausage as desired.

How do I prevent the sauce from curdling?

Simmer cream and milk gently; avoid boiling. Stir cheeses in gradually over low heat for a smooth sauce.

Are there ways to add vegetables?

You can include steamed broccoli, peas, or sautéed mushrooms for more flavor and texture variety.

What cheese alternatives can I use?

Gruyère or Monterey Jack work well alongside or instead of cheddar for a different cheesy profile.

How should leftovers be stored?

Cool completely and store in an airtight container in the refrigerator for up to 3 days. Reheat gently.

Mac and Cheese Chicken Alfredo

Hearty casserole of pasta, chicken, creamy cheese sauce, and crisp golden topping for comforting dinners.

Prep Time
20 mins
Cook Time
35 mins
Total Duration
55 mins
Authored by Lana Bright

Recipe Type Hearty Dinners

Skill Level Medium

Cuisine Style American

Recipe Yield 6 Serving Size

Diet Preferences None specified

What You'll Need

Pasta & Chicken

01 12 ounces elbow macaroni
02 2 cups cooked chicken breast, diced or shredded

Cheese & Dairy

01 2 cups shredded mozzarella cheese
02 1 cup shredded sharp cheddar cheese
03 1/2 cup grated Parmesan cheese
04 2 cups heavy cream
05 1 cup whole milk
06 4 tablespoons unsalted butter

Sauce & Flavorings

01 4 cloves garlic, minced
02 1/2 teaspoon salt
03 1/2 teaspoon freshly ground black pepper
04 1/4 teaspoon ground nutmeg

Topping

01 1 cup panko breadcrumbs
02 2 tablespoons unsalted butter, melted
03 2 tablespoons grated Parmesan cheese
04 2 tablespoons fresh parsley, chopped

Directions

Step 01

Oven Preparation: Preheat oven to 375°F. Grease a 9x13-inch baking dish.

Step 02

Cook Pasta: Boil macaroni according to package directions until al dente. Drain and set aside.

Step 03

Prepare Garlic Butter: Melt 4 tablespoons unsalted butter in a large saucepan over medium heat. Add minced garlic and sauté for 1–2 minutes until aromatic.

Step 04

Build Alfredo Sauce: Pour in heavy cream and whole milk. Season with salt, black pepper, and nutmeg. Heat gently to a simmer without boiling.

Step 05

Incorporate Cheeses: Reduce heat to low and whisk in mozzarella, cheddar, and Parmesan cheese until completely melted and smooth.

Step 06

Combine Components: Stir in cooked macaroni and chicken breast, ensuring all pieces are evenly coated with the sauce.

Step 07

Transfer to Baking Dish: Pour the mixture into the prepared baking dish, spreading evenly.

Step 08

Prepare Topping: Mix panko breadcrumbs, melted butter, and grated Parmesan cheese together in a bowl. Sprinkle uniformly over the casserole.

Step 09

Bake: Bake uncovered for 20–25 minutes until the topping is golden brown and the sauce is bubbling at the edges.

Step 10

Rest and Garnish: Remove from the oven and allow to rest for 5 minutes. Garnish with chopped fresh parsley prior to serving as preferred.

Tools You'll Need

  • Large saucepan
  • Large pot
  • 9x13-inch baking dish
  • Mixing bowls
  • Whisk
  • Measuring cups
  • Measuring spoons

Allergy Information

Review each ingredient to identify potential allergens, and consult a healthcare professional if you're unsure.
  • Contains milk products including cheese, butter, cream, and milk.
  • Contains wheat from pasta and breadcrumbs.
  • Some brands of pasta may contain egg—verify packaging.

Nutrition Details (Per Serving)

This nutritional data is for reference only and isn't a substitute for medical advice.
  • Caloric Value: 670
  • Fats: 39 grams
  • Carbohydrates: 45 grams
  • Proteins: 34 grams